An efficient and convergent route towards water-soluble, chiral and amphiphilic macrocycles

被引：15

作者：

Bhattacharyya, T ^{[1
]}

Nilsson, UJ ^{[1
]}

机构：

[1] Univ Lund, Dept Organ Chem 2, SE-22100 Lund, Sweden

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(01)00301-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical procedure for the synthesis of water-soluble, chiral and amphiphilic macrocyclic molecules is described. Acylation of p-xylylene diamine with Fmoc-protected glycine and aspartic acid, followed by removal of the Fmoc moiety afforded amino acid:p-xylene conjugates as free diamines. These diamines were converted to symmetrical and unsymmetrical macrocycles via stepwise urea formation using p-nitrophenyl chloroformate. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2873 / 2875

页数：3

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