Endothelin-Biology and disease

被引：158

作者：

Khimji, Al-Karim ^{[1
]}

Rockey, Don C. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Div Digest & Liver Dis, Dept Internal Med, Dallas, TX 75390 USA

来源：

CELLULAR SIGNALLING | 2010年 / 22卷 / 11期

关键词：

Endothelin-converting enzyme; Weilbel-Palade bodies; Sarafatoxin; Myofibroblasts; Nitric oxide; Wound healing; CHRONIC HEART-FAILURE; PROTEIN-KINASE-C; CHRONIC-RENAL-FAILURE; SMOOTH-MUSCLE-CELLS; PLACEBO-CONTROLLED TRIAL; PORCINE CORONARY-ARTERY; CONVERTING ENZYME ECE-1; B RECEPTOR EXPRESSION; NITRIC-OXIDE SYNTHASE; BASAL VASCULAR-TONE;

D O I：

10.1016/j.cellsig.2010.05.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endothelins are important mediators of physiological and pathophysiologic processes including cardiovascular disorders, pulmonary disease, renal diseases and many others. Additionally, endothelins are involved in many other important processes such as development, cancer biology, wound healing, and even neurotransmission. Here, we review the cell and molecular biology as well as the prominent pathophysiological aspects of the endothelin system. (C) 2010 Published by Elsevier Inc.

引用

页码：1615 / 1625

页数：11

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