Evaluation of electrophoretic method versus chromatographic, potentiometric and absorptiometric methodologies for determing pKa values of quinolones in hydroorganic mixtures

被引：39

作者：

Barbosa, J ^{[1
]}

Barrón, D ^{[1
]}

Cano, J ^{[1
]}

Jiménez-Lozano, E ^{[1
]}

Sanz-Nebot, V ^{[1
]}

Toro, I ^{[1
]}

机构：

[1] Univ Barcelona, Dept Analyt Chem, E-08028 Barcelona, Spain

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2001年 / 24卷 / 5-6期

关键词：

quinolones; dissociation constants; acetonitrile-water mixture; electrophoretic mobility; liquid chromatography; potentiometry; UV visible spectrophotometry;

D O I：

10.1016/S0731-7085(00)00561-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The advantages of using capillary electrophoresis (CE) over other methodologies for determining pK(a) values of drugs in hydroorganic media are discussed. The focus of the discussion based upon the pK(a), values of a series of quinolones determined in acetonitrile (MeCN)-water mixtures by CE, liquid chromatography, potentiometric, and spectrophotometric methods. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：1087 / 1098

页数：12

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