Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium (II) acetate and tetra-n-butylammonium salts

被引：108

作者：

Lee, CKY

Holmes, AB

Ley, SV

McConvey, IF

Al-Duri, B

Leeke, GA

Santos, RCD

Seville, JPK

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Melbourne, Bio21 Inst, Parkville, Vic 3010, Australia

[3] AstraZeneca Proc Res & Dev, Macclesfield SK10 2NA, Cheshire, England

[4] Univ Birmingham, Dept Chem Engn, Birmingham B15 2TT, W Midlands, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 16期

关键词：

D O I：

10.1039/b418669a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Suzuki cross-coupling reactions are effected in both conventional organic solvents, under continuous flow conditions at 70 degrees C, and in batch mode in supercritical carbon dioxide (scCO(2)), at temperatures as low as 40 degrees C in the presence of palladium(II) acetate microencapsulated in polyurea [PdEnCat](TM) and tetra-n-butylammonium salts.

引用

收藏

页码：2175 / 2177

页数：3

相关论文

共 14 条

[1]

[Anonymous], 1999, CHEM SYNTHESIS USING

[2] Palladium-catalysed cross-coupling reactions in supercritical carbon dioxide [J].

Early, TR ;

Gordon, RS ;

Carroll, MA ;

Holmes, AB ;

Shute, RE ;

McConvey, IF .

CHEMICAL COMMUNICATIONS, 2001, (19) :1966-1967

[3] Continuous catalytic reactions in supercritical fluids [J].

Hyde, JR ;

Licence, P ;

Carter, D ;

Poliakoff, M .

APPLIED CATALYSIS A-GENERAL, 2001, 222 (1-2) :119-131

[4] Polyurea-encapsulated palladium(II) acetate: a robust and recyclable catalyst for use in conventional and supercritical media [J].

Ley, SV ;

Ramarao, C ;

Gordon, RS ;

Holmes, AB ;

Morrison, AJ ;

McConvey, IF ;

Shirley, IM ;

Smith, SC ;

Smith, MD .

CHEMICAL COMMUNICATIONS, 2002, (10) :1134-1135

[5] Chemical reactions in supercritical carbon dioxide: from laboratory to commercial plant [J].

Licence, P ;

Ke, J ;

Sokolova, M ;

Ross, SK ;

Poliakoff, M .

GREEN CHEMISTRY, 2003, 5 (02) :99-104

[6] PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF ORGANOBORON COMPOUNDS [J].

MIYAURA, N ;

SUZUKI, A .

CHEMICAL REVIEWS, 1995, 95 (07) :2457-2483

[7] THE PALLADIUM-CATALYZED CROSS-COUPLING REACTION OF PHENYLBORONIC ACID WITH HALOARENES IN THE PRESENCE OF BASES [J].

MIYAURA, N ;

YANAGI, T ;

SUZUKI, A .

SYNTHETIC COMMUNICATIONS, 1981, 11 (07) :513-519

[8] The use of supercritical fluids in synthetic organic chemistry [J].

Oakes, RS ;

Clifford, AA ;

Rayner, CM .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001, (09) :917-941

[9]

Poliakoff M, 1999, CHEM IND-LONDON, P750

[10] Encapsulation of palladium in polyurea microcapsules [J].

Ramarao, C ;

Ley, SV ;

Smith, SC ;

Shirley, IM ;

DeAlmeida, N .

CHEMICAL COMMUNICATIONS, 2002, (10) :1132-1133