Trisomy 7 and trisomy 8 in dividing and non-dividing tumor cells in Dupuytren's disease

被引：18

作者：

Dal Cin, P

De Smet, L

Sciot, R

Van Damme, B

Van den Berghe, H

机构：

[1] Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

[2] Univ Leuven, Dept Orthoped Surg, B-3000 Louvain, Belgium

[3] Univ Leuven, Dept Pathol, B-3000 Louvain, Belgium

来源：

CANCER GENETICS AND CYTOGENETICS | 1999年 / 108卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(98)00126-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic and molecular cytogenetic analysis is reported in a series of 40 tissue samples from 36 patients with Dupuytren's disease, presenting as palmar and/or finger nodules. No consistent structural chromosome changes could be found. instead recurrent clonal numerical abnormalities were demonstrated in 22 of 40 tissue nodules, involving trisomies of chromosome 7 or 8 and loss of the Y chromosome. In addition, we showed that trisomy 7 and trisomy 8 were also present in non-dividing cells. (C) Elsevier Science Inc., 1998.

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页码：137 / 140

页数：4

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