Cancer epigenetics is no Mickey Mouse

被引：36

作者：

Feinberg, AP

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

来源：

CANCER CELL | 2005年 / 8卷 / 04期

关键词：

D O I：

10.1016/j.ccr.2005.09.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Epigenetic changes are the most common alterations in human cancer, but it has been difficult to sort out cause and effect from studies of human tumors. Several recent nonlethal mouse models implicate both hypomethylation and loss of imprinting(LOI) in tumor formation, including a paper in this issue of Cancer Cell showing that transient hypomethylation in ES cells causes LOI and liver and intestinal tumors (Holm et al., 2005). Hypomethylation appears to be a critical determinant of cancer, affecting chromosomal stability and specific gene targets.

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页码：267 / 268

页数：2

相关论文

共 13 条

[1]

Loss of IGF2 imprinting:: A potential marker of colorectal cancer risk [J].

Cui, HM ;

Cruz-Correa, M ;

Giardiello, FM ;

Hutcheon, DF ;

Kafonek, DR ;

Brandenburg, S ;

Wu, YQ ;

He, XB ;

Powe, NR ;

Feinberg, AP .

SCIENCE, 2003, 299 (5613) :1753-1755

[2]

Chromosomal instability and tumors promoted by DNA hypomethylation [J].

Eden, A ;

Gaudet, F ;

Waghmare, A ;

Jaenisch, R .

SCIENCE, 2003, 300 (5618) :455-455

[3]

Timeline - The history of cancer epigenetics [J].

Feinberg, AP ;

Tycko, B .

NATURE REVIEWS CANCER, 2004, 4 (02) :143-153

[4]

Induction of tumors in mice by genomic hypomethylation [J].

Gaudet, F ;

Hodgson, JG ;

Eden, A ;

Jackson-Grusby, L ;

Dausman, J ;

Gray, JW ;

Leonhardt, H ;

Jaenisch, R .

SCIENCE, 2003, 300 (5618) :489-492

[5]

HOLM TM, 2005, IN PRESS CANC CELL

[6]

The fundamental role of epigenetic events in cancer [J].

Jones, PA ;

Baylin, SB .

NATURE REVIEWS GENETICS, 2002, 3 (06) :415-428

[7]

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability [J].

Peters, AHFM ;

O'Carroll, D ;

Scherthan, H ;

Mechtler, K ;

Sauer, S ;

Schöfer, C ;

Weipoltshammer, K ;

Pagani, M ;

Lachner, M ;

Kohlmaier, A ;

Opravil, S ;

Doyle, M ;

Sibilia, M ;

Jenuwein, T .

CELL, 2001, 107 (03) :323-337

[8]

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice [J].

Roberts, CWM ;

Galusha, SA ;

McMenamin, ME ;

Fletcher, CDM ;

Orkin, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (25) :13796-13800

[9]

Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice [J].

Sakatani, T ;

Kaneda, A ;

Iacobuzio-Donahue, CA ;

Carter, MG ;

Witzel, SD ;

Okano, H ;

Ko, MSH ;

Ohlsson, R ;

Longo, DL ;

Feinberg, AP .

SCIENCE, 2005, 307 (5717) :1976-1978

[10]

Deficiency of Mbd2 suppresses intestinal tumorigenesis [J].

Sansom, OJ ;

Berger, J ;

Bishop, SM ;

Hendrich, B ;

Bird, A ;

Clarke, AR .

NATURE GENETICS, 2003, 34 (02) :145-147