West Nile Virus RNA Not Detected in Urine of 40 People Tested 6 Years After Acute West Nile Virus Disease

被引:39
作者
Gibney, Katherine B. [1 ,2 ]
Lanciotti, Robert S. [1 ]
Sejvar, James J. [1 ]
Nugent, C. Thomas [3 ]
Linnen, Jeffrey M. [3 ]
Delorey, Mark J. [1 ]
Lehman, Jennifer A. [1 ]
Boswell, Erin N. [1 ]
Staples, J. Erin [1 ]
Fischer, Marc [1 ]
机构
[1] Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO 80521 USA
[2] Ctr Dis Control & Prevent, Epidem Intelligence Serv Off, Atlanta, GA USA
[3] Gen Probe Inc, San Diego, CA USA
关键词
INFECTION;
D O I
10.1093/infdis/jiq057
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
West Nile virus (WNV) causes an acute infection that is usually cleared by an effective immune response after several days of viremia. However, a recent study detected WNV RNA in the urine of 5 of 25 persons (20%) tested several years after their initial acute WNV disease. We evaluated an established cohort of 40 persons >6 years after initial infection with WNV. Urine collected from all participants tested negative for WNV RNA by reverse-transcription polymerase chain reaction and transcription-mediated amplification. Prospective studies are needed to determine if and for how long WNV persists in urine following WNV disease.
引用
收藏
页码:344 / 347
页数:4
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