P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues

被引:93
作者
Scarborough, PE [1 ]
Ma, JX [1 ]
Qu, W [1 ]
Zeldin, DC [1 ]
机构
[1] NIEHS, Pulm Pathobiol Lab, NIH, Res Triangle Pk, NC 27709 USA
关键词
D O I
10.1081/DMR-100101915
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism.
引用
收藏
页码:205 / 234
页数:30
相关论文
共 87 条
[1]   MEMBRANE TOPOLOGY OF THE MAMMALIAN P450-CYTOCHROMES [J].
BLACK, SD .
FASEB JOURNAL, 1992, 6 (02) :680-685
[2]   Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors [J].
Campbell, WB ;
Gebremedhin, D ;
Pratt, PF ;
Harder, DR .
CIRCULATION RESEARCH, 1996, 78 (03) :415-423
[3]  
CAPDEVILA J, 1983, ENDOCRINOLOGY, V113, P421
[4]  
CAPDEVILA JH, 1992, J BIOL CHEM, V267, P21720
[5]  
CAPDEVILA JH, 1990, J BIOL CHEM, V265, P10865
[6]   CYTOCHROME-P450 AND THE ARACHIDONATE CASCADE [J].
CAPDEVILA, JH ;
FALCK, JR ;
ESTABROOK, RW .
FASEB JOURNAL, 1992, 6 (02) :731-736
[7]  
CAPDEVILA JH, 1996, ADV MOL CEL, V14, P317
[8]  
Capdevila Jorge H., 1995, P443
[9]  
CARROLL MA, 1992, J PHARMACOL EXP THER, V260, P104
[10]  
Carroll MA, 1997, ADV EXP MED BIOL, V407, P255