The anticancer activity of propolis

被引：21

作者：

Sawicka, Diana ^{[2
]}

Car, Halina ^{[1
]}

Borawska, Maria Halina ^{[3
]}

Niklinski, Jacek ^{[2
]}

机构：

[1] Med Univ Bialystok, Dept Expt Pharmacol, PL-15295 Bialystok, Poland

[2] Med Univ Bialystok, Ctr Med Expt, PL-15295 Bialystok, Poland

[3] Med Univ Bialystok, Dept Bromatol, PL-15295 Bialystok, Poland

来源：

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2012年 / 50卷 / 01期

关键词：

cancer; propolis; CAPE; chrysin; apoptosis; proliferation; ACID PHENETHYL ESTER; CELL-CYCLE ARREST; C6; GLIOMA-CELLS; CANCER CELLS; IN-VITRO; ANTIMICROBIAL ACTIVITY; ANTIVIRAL ACTIVITY; INDUCED APOPTOSIS; CHRYSIN; PATHWAY;

D O I：

10.5603/FHC.2012.0004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Propolis and its compounds have been the subject of many studies due to their antimicrobial and anti-inflammatory activity; however, it is now known that they also possess antitumor properties. This review aims to summarize the results of studies on the mechanism of activity of propolis and its active compounds such as CAPE and chrysin in the apoptotic process, and their influence on the proliferation of cancer cells. Our review shows that propolis and its presented compounds induce apoptosis pathways in cancer cells. The antiproliferative effects of propolis, CAPE or chrysin in cancer cells are the result of the suppression of complexes of cyclins, as well as cell cycle arrest. The results of in vitro and in vivo studies suggest that propolis, CAPE and chrysin may inhibit tumor cell progression and may be useful as potential chemotherapeutic or chemopreventive anticancer drugs. (Folio Histochemica et Cytobiologica 2012, Vol. 50, No. 1, 25-37)

引用

页码：25 / 37

页数：13

共 74 条

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