Bend ribbon-forming tetrahydrofuran amino acids

被引：41

作者：

Smith, MD

Claridge, TDW

Sansom, MSP

Fleet, GWJ

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

[3] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 21期

关键词：

D O I：

10.1039/b307707c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Short oligomeric chains of C-glycosyl beta-D-arabinofuranose configured tetrahydrofuran amino acids ( where the C-2 and C-5 substituents of the tetrahydrofuran ring are cis to each other) exhibit a well-defined repeating turn secondary structure stabilised by ( i, i - 2) inter-residue hydrogen bonds. This is in contrast to the epimeric alpha-D-arabinofuranose oligomer ( where the C-2 and C-5 substituents of the tetrahydrofuran ring are trans to each other) in which there is no indication of any secondary structure in solution.

引用

页码：3647 / 3655

页数：9

共 47 条

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[2]

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