Direct amination of aryl halides with ammonia

被引：200

作者：

Aubin, Yoann ^{[2
]}

Fischmeister, Cedric ^{[1
]}

Thomas, Christophe M. ^{[3
]}

Renaud, Jean-Luc ^{[2
]}

机构：

[1] Univ Rennes 1, UMR 6226, CNRS, F-35042 Rennes, France

[2] Univ Caen, Lab Chim Mol & Thioorgan, UMR 6507, ENSICAEN,INC3M,FR 3038, F-14050 Caen, France

[3] Chim ParisTech, UMR CNRS 7223, F-75231 Paris 05, France

来源：

CHEMICAL SOCIETY REVIEWS | 2010年 / 39卷 / 11期

关键词：

CATALYZED C-N; CROSS-COUPLING REACTIONS; BOND-FORMING REACTIONS; LONG-LIVED CATALYSTS; AQUEOUS AMMONIA; PRIMARY ANILINES; COPPER; CHLORIDES; EFFICIENT; LIGANDS;

D O I：

10.1039/c003692g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The traditional homogeneous access to aromatic amine derivatives is a nucleophilic aromatic substitution of the corresponding aryl halides. The halogen atom is usually relatively inert to amination reaction unless it is activated by the presence of electron withdrawing groups. Consequently, there has been particular emphasis over the past decade on the synthesis of metal complexes that are active catalysts for the preparation of aromatic amines. This tutorial review focuses on the use of metal-based complexes for the direct amination of aryl halides with ammonia.

引用

页码：4130 / 4145

页数：16

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