In vivo theranostics with near-infrared-emitting carbon dots-highly efficient photothermal therapy based on passive targeting after intravenous administration

被引：375

作者：

Bao, Xin ^{[1
,2
]}

Yuan, Ye ^{[3
]}

Chen, Jingqin ^{[4
]}

Zhang, Bohan ^{[1
,2
]}

Li, Di ^{[1
]}

Zhou, Ding ^{[1
]}

Jing, Pengtao ^{[1
]}

Xu, Guiying ^{[5
]}

Wang, Yingli ^{[5
]}

Hola, Katerina ^{[6
]}

Shen, Dezhen ^{[1
]}

Wu, Changfeng ^{[3
]}

Song, Liang ^{[4
,7
]}

Liu, Chengbo ^{[4
]}

Zboril, Radek ^{[6
]}

Qu, Songnan ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, State Key Lab Luminescence & Applicat, 3888 Dong Nanhu Rd, Changchun 130033, Jilin, Peoples R China

[2] Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100190, Peoples R China

[3] Southern Univ Sci & Engn, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

[4] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Res Lab Biomed Opt & Mol Imaging, Shenzhen 518055, Peoples R China

[5] Jilin Prov Tumor Hosp, Changchun, Jilin, Peoples R China

[6] Palacky Univ Olomouc, Dept Phys Chem, Reg Ctr Adv Technol & Mat, Fac Sci, Olomouc 78371, Czech Republic

[7] Shenzhen Inst Adv Technol, CAS Key Lab Hlth Informat, Shenzhen 518055, Peoples R China

来源：

LIGHT-SCIENCE & APPLICATIONS | 2018年 / 7卷

基金：

中国国家自然科学基金;

关键词：

SEMICONDUCTING POLYMER NANOPARTICLES; GRAPHENE QUANTUM DOTS; NANODOTS SYNTHESIS; TUMOR UPTAKE; FLUORESCENT; CELLS; AGENT; PHOTOCATALYSTS; NANOSPHERES; OXIDE;

D O I：

10.1038/s41377-018-0090-1

中图分类号：

O43 [光学];

学科分类号：

070207 [光学];

摘要：

Carbon dots that exhibit near-infrared fluorescence (NIR CDs) are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents. Despite progress in the synthesis of NIR CDs, there remains a key obstacle to using them as an in vivo theranostic agent. This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy (PTT) in mouse models (conversion efficiency of 59%) and can be readily visualized by photoluminescence and photoacoustic imaging. The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting. Contrary to all other nanomaterials that have been tested in biomedicine, they are excreted through the body's renal filtration system. Moreover, after intravenous injection, NIR CDs are accumulated in tumor tissue via passive targeting, without any active species such as antibodies. Due to their accumulation in tumor tissue without the need for intratumor injection, high photothermal conversion, excel lent optical and photoacoustic imaging performance, and renal excretion, the developed CDs are suitable for transfer to clinical biomedical practice.

引用

页数：11

共 65 条

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