Nonfouling polymer brushes via surface-initiated, two-component atom transfer radical polymerization

被引：156

作者：

Bernards, Matthew T. ^{[1
]}

Cheng, Gang ^{[1
]}

Zhang, Zheng ^{[1
]}

Chen, Shengfu ^{[1
]}

Jiang, Shaoyi ^{[1
]}

机构：

[1] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA

来源：

MACROMOLECULES | 2008年 / 41卷 / 12期

关键词：

D O I：

10.1021/ma800185y

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A significant challenge in the field of biomaterials is the nonspecific adsorption of proteins. It has been suggested that overall neutral materials composed of mixed charge components present protein-resistant properties. This work describes the development of a novel nonfouling polymer brush formed from a surface-initiated, two-component atom transfer radical polymerization. The polymer brushes are composed of varying mixtures of positively and negatively charged monomers depending on the polymerization conditions. The polymer brushes were characterized by both atomic force microscopy and electron spectroscopy for chemical analysis to determine the thickness and composition, respectively. The nonspecific adsorption of fibrinogen, lysozyme, and bovine serum albumin was measured using a surface plasmon resonance biosensor. It was found that when the polymer brush surface coating was formed as a statistical copolymer from the two charged components, it had nonfouling properties for all three probe proteins.

引用

页码：4216 / 4219

页数：4

共 21 条

[1]

BOOZER CL, 2003, SENSOR ACTUAT B-CHEM, V20, P22

[2] Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: Insights into nonfouling properties of zwitterionic materials [J].

Chen, SF ;

Zheng, J ;

Li, LY ;

Jiang, SY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (41) :14473-14478

[3] A new avenue to nonfouling materials [J].

Chen, Shengfu ;

Jiang, Shaoyi .

ADVANCED MATERIALS, 2008, 20 (02) :335-+

[4] Strong resistance of a thin crystalline layer of balanced charged groups to protein adsorption [J].

Chen, Shengfu ;

Yu, Fuchen ;

Yu, Qiuming ;

He, Yi ;

Jiang, Shaoyi .

LANGMUIR, 2006, 22 (19) :8186-8191

[5] Inhibition of bacterial adhesion and biofilm formation on zwitterionic surfaces [J].

Cheng, Gang ;

Zhang, Zheng ;

Chen, Shengfu ;

Bryers, James D. ;

Jiang, Shaoyi .

BIOMATERIALS, 2007, 28 (29) :4192-4199

[6] Polymer brushes via surface-initiated polymerizations [J].

Edmondson, S ;

Osborne, VL ;

Huck, WTS .

CHEMICAL SOCIETY REVIEWS, 2004, 33 (01) :14-22

[7] Adsorption of fibrinogen and lysozyme on silicon grafted with poly(2-methacryloyloxyethyl phosphorylcholine) via surface-initiated atom transfer radical polymerization [J].

Feng, W ;

Zhu, SP ;

Ishihara, K ;

Brash, JL .

LANGMUIR, 2005, 21 (13) :5980-5987

[8] OXIDATION OF POLYETHYLENE GLYCOLS BY ALCOHOL-DEHYDROGENASE [J].

HEROLD, DA ;

KEIL, K ;

BRUNS, DE .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (01) :73-76

[9] Zwitterionic SAMs that resist nonspecific adsorption of protein from aqueous buffer [J].

Holmlin, RE ;

Chen, XX ;

Chapman, RG ;

Takayama, S ;

Whitesides, GM .

LANGMUIR, 2001, 17 (09) :2841-2850

[10] Understanding the nonfouling mechanism of surfaces through molecular simulations of sugar-based self-assembled monolayers [J].

Hower, Jason C. ;

He, Yi ;

Bernards, Matthew T. ;

Jiang, Shaoyi .

JOURNAL OF CHEMICAL PHYSICS, 2006, 125 (21)

← 1 2 3 →