An approach for continuous-flow processing of reactions that involve the in situ formation of organic products

被引：29

作者：

Kelly, Christopher B. ^{[1
]}

Lee, Christopher ^{[1
]}

Leadbeater, Nicholas E. ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 02期

基金：

美国国家科学基金会;

关键词：

Flow chemistry; Microwave heating; Suzuki coupling; Coumarins; Dihydropyridines; MICROWAVE-PROMOTED SUZUKI; SCALE-UP; CATALYST;

D O I：

10.1016/j.tetlet.2010.11.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple adaptation allows batch protocols developed using microwave heating that involve formation of solid organic products to be scaled up using conventionally-heated flow chemistry with minimal or no re-optimization or modification. The product stream is intercepted with a flow of a suitable organic solvent upon exiting the heated zone, this solubilizing the product and allowing it to pass through the back-pressure regulator without aggregation of particulate material. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：263 / 265

页数：3

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