CRISPR-based adaptive immune systems

被引：367

作者：

Terns, Michael P. ^{[1
,2
]}

Terns, Rebecca M. ^{[1
]}

机构：

[1] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

[2] Univ Georgia, Dept Genet, Athens, GA 30602 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2011年 / 14卷 / 03期

关键词：

PROVIDES ACQUIRED-RESISTANCE; HORIZONTAL GENE-TRANSFER; SMALL RNA; BACTERIA; REPEATS; SULFOLOBUS; DEFENSE; DNA; IDENTIFICATION; SEQUENCE;

D O I：

10.1016/j.mib.2011.03.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

CRISPR-Cas systems are recently discovered, RNA-based immune systems that control invasions of viruses and plasmids in archaea and bacteria. Prokaryotes with CRISPR-Cas immune systems capture short invader sequences within the CRISPR loci in their genomes, and small RNAs produced from the CRISPR loci (CRISPR (cr)RNAs) guide Cas proteins to recognize and degrade (or otherwise silence) the invading nucleic acids. There are multiple variations of the pathway found among prokaryotes, each mediated by largely distinct components and mechanisms that we are only beginning to delineate. Here we will review our current understanding of the remarkable CRISPR-Cas pathways with particular attention to studies relevant to systems found in the archaea.

引用

页码：321 / 327

页数：7

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