Inhibitors of membrane receptors involved with leukocute extravasation

被引：16

作者：

Bendas, G ^{[1
]}

机构：

[1] Univ Bonn, Inst Pharmaceut Chem, Dept Pharm, D-53121 Bonn, Germany

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 06期

关键词：

adhesion molecules; autoimmune disease; endothelium; inflammation; integrins; leukocytes; selectins;

D O I：

10.2174/1389557054023279

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The migration of leukocytes from the blood stream to sites of infection is a key event in cellular immune response, mediated by multiple types of molecules including several adhesion receptors. The inhibition of adhesion receptors holds great promise for novel therapeutical strategies, to treat chronic inflammatory disorders or autoimmune diseases. This review reports on recent advances in adhesion-based therapeutics and focuses on structural classification of selectin and integrin inhibitors.

引用

页码：575 / 584

页数：10

共 84 条

[1] A small-molecule, tight-binding inhibitor of the integrin α4β1 blocks antigen-induced airway responses and inflammation in experimental asthma in sheep [J].

Abraham, WM ;

Gill, A ;

Ahmed, A ;

Sielczak, MW ;

Lauredo, IT ;

Botinnikova, Y ;

Lin, KC ;

Pepinsky, B ;

Leone, DR ;

Lobb, RR ;

Adams, SP .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (02) :603-611

[2] Searching for medicine's sweet spot [J].

Alper, J .

SCIENCE, 2001, 291 (5512) :2338-2343

[3] Targeting ICAM-1/LFA-1 interaction for controlling autoimmune diseases: designing peptide and small molecule inhibitors [J].

Anderson, ME ;

Siahaan, TJ .

PEPTIDES, 2003, 24 (03) :487-501

[4] Development of synthetic pan-selectin antagonists: A new treatment strategy for chronic inflammation in asthma [J].

Aydt, E ;

Wolff, G .

PATHOBIOLOGY, 2002, 70 (05) :297-301

[5] Leukocyte adhesion deficiency type II [J].

Becker, DJ ;

Lowe, JB .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1999, 1455 (2-3) :193-204

[6] Interfering with leukocyte rolling -: a promising therapeutic approach in inflammatory skin disorders? [J].

Boehncke, WH ;

Schön, MP .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2003, 24 (02) :49-52

[7] ONLY SIMULTANEOUS BLOCKING OF THE L-SELECTIN AND P-SELECTIN COMPLETELY INHIBITS NEUTROPHIL MIGRATION INTO MOUSE PERITONEUM [J].

BOSSE, R ;

VESTWEBER, D .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (12) :3019-3024

[8] Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists [J].

Chen, L ;

Trilles, R ;

Miklowski, D ;

Huang, TN ;

Fry, D ;

Campbell, R ;

Rowan, K ;

Schwinge, V ;

Tilley, JW .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (12) :1679-1682

[9] Identification of ligand binding sites on integrin α4β1 through chemical cross-linking [J].

Chen, LL ;

Lobb, RR ;

Cuervo, JH ;

Lin, KC ;

Adams, SP ;

Pepinsky, RB .

BIOCHEMISTRY, 1998, 37 (24) :8743-8753

[10] Recent Progress in the Design of Selectin Inhibitors [J].

Chhabra, Siri Ram ;

Rahim, Aisyah S. Abdul ;

Kellam, Barrie .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2003, 3 (07) :679-687

← 1 2 3 4 5 6 7 8 9 →