An update on the amyloid hypothesis

被引：29

作者：

Eckman, Christopher B. ^{[1
]}

Eckman, Elizabeth A. ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, Dept Neurosci, Jacksonville, FL 32224 USA

来源：

NEUROLOGIC CLINICS | 2007年 / 25卷 / 03期

关键词：

LONG-TERM POTENTIATION; ALZHEIMERS-DISEASE; BETA-PROTEIN; PRECURSOR PROTEIN; A-BETA; IN-VITRO; PATHOGENIC MUTATION; PLAQUE CORE; MOUSE MODEL; APP GENE;

D O I：

10.1016/j.ncl.2007.03.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is a devastating neurodegenerative disease. To rationally develop novel therapeutic and/or preventative agents for AD, an understanding of the etiology and pathogenesis of this complex disease is necessary. This article examines the evidence for the amyloid hypothesis of AD pathogenesis and discusses how it relates to the neurological and neuropathological features of AD, the known genetic risk factors and causative mutations, and the heightened risk associated with advanced age.

引用

页码：669 / +

页数：15

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