Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis:: Evidence for a gene dosage effect on linezolid MICs

被引：52

作者：

Ruggero, KA

Schroeder, LK

Schreckenberger, PC

Mankin, AS

Quinn, JP

机构：

[1] Rush Univ, Cook Cty Hosp, Chicago, IL 60612 USA

[2] Univ Illinois, Ctr Pharmaceut Biotechnol, Chicago, IL 60607 USA

[3] Univ Illinois, Dept Pathol, Chicago, IL 60612 USA

[4] Univ Illinois, Dept Internal Med, Infect Dis Sect, Chicago, IL 60612 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2003年 / 47卷 / 03期

关键词：

D O I：

10.1016/S0732-8893(03)00153-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Resistance to linezolid among Enterococcus faecium and Enterococcus faecalis isolates has been reported in patients who receive a prolonged course of the drug. We report two cases of linezolid-resistant Enterococcus faecalis that occurred in patients who previously received linezolid for infections with vancomycin-resistant Enterococcus faecium. Both isolates had the G2576U mutation in the 23S rRNA previously reported in isolates of Enterococcus faecium. The number of gene copies mutated in the 23S rRNA correlated with the level of resistance. (C) 2003 Elsevier Inc. All rights reserved.

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页码：511 / 513

页数：3

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