Microbiologically-assisted hemisynthesis of 1α-hydroxydrimenol

被引：9

作者：

Aranda, G

Cortés, M

Maurs, M

Azerad, R ^{[1
]}

机构：

[1] Univ Paris 05, Lab Chim & Biochim Pharmacol & Toxicol, UMR 8601, F-75006 Paris, France

[2] Ecole Polytech, Synth Organ Lab, UMR 7652, F-91128 Palaiseau, France

[3] Pontificia Univ Catolica Chile, Fac Quim, Santiago, Chile

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 14期

关键词：

D O I：

10.1016/S0957-4166(01)00353-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The hemisynthesis of 1 alpha -hydroxydrimenol has been selected to illustrate a synthetic route involving an initial microbial 3 beta -hydroxylation of a drimenol derivative followed by a functionalization transfer to position 1 alpha, thus generating a new potentially bioactive hydroxylated terpenic compound, Several methods have been investigated for the protection and the regeneration of the 7,8-double bond of drimenyl derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2013 / 2018

页数：6

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