Technology Insight: metabonomics in gastroenterology - basic principles and potential clinical applications

被引：32

作者：

Bjerrum, Jacob T.

Nielsen, Ole H. ^{[3
]}

Wang, Yulan L. ^{[1
]}

Olsen, Jorgen ^{[2
]}

机构：

[1] Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China

[2] Univ Copenhagen, Panum Inst, Dept Mol & Cellular Med, DK-1168 Copenhagen, Denmark

[3] Univ Copenhagen, Herlev Hosp, Med Sect, Gastroenterol Unit, DK-2730 Herlev, Denmark

来源：

NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY | 2008年 / 5卷 / 06期

关键词：

chemometrics; gastroenterology; metabonomics; nuclear magnetic resonance spectroscopy; systems biology;

D O I：

10.1038/ncpgasthep1125

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Metabonomics-the study of metabolic changes in an integrated biologic system-is an emerging field. This discipline joins the other 'omics'(genomics, transcriptomics and proteomics) to give rise to a comprehensive, systems-biology approach to the evaluation of holistic in vivo function. Metabonomics, especially when based on nuclear magnetic resonance spectroscopy, has the potential to identify biomarkers and prognostic factors, enhance clinical diagnosis, and expand hypothesis generation. As a consequence, the use of metabonomics has been extensively explored in the past decade, and applied successfully to the study of human diseases, toxicology, microbes, nutrition, and plant biology. This Review introduces the basic principles of nuclear magnetic resonance spectroscopy and commonly used tools for multivariate data analysis, before considering the applications and future potential of metabonomics in basic and clinical research, with emphasis on applications in the field of gastroenterology.

引用

页码：332 / 343

页数：12

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