Stereochemical determination of thuggacins A-C, highly active antibiotics from the myxobacterium Sorangium cellulosum

被引：43

作者：

Bock, Martin ^{[1
,2
]}

Buntin, Kathrin ^{[3
]}

Mueller, Rolf ^{[3
,4
]}

Kirschning, Andreas ^{[1
,2
]}

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

[2] Leibniz Univ Hannover, BMWZ, D-30167 Hannover, Germany

[3] Univ Saarland, Inst Pharmazeut Biotechnol, D-66041 Saarbrucken, Germany

[4] HZI, D-38124 Braunschweig, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 12期

关键词：

antibiotics; gene analysis; macrolactones; Mosher ester; structure elucidation;

D O I：

10.1002/anie.200704897

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemistry and biology meet in the structure elucidation of the antibiotics thuggacins A-C. The absolute configuration of all stereogenic centers in the thuggacins was confirmed through a combination of chemical derivatization, NMR analysis, molecular modeling, and bioinformatic analysis of the thuggacin biosynthetic genes. (Chemical Equation Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2308 / 2311

页数：4

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