Metal Organic Framework-Based Stimuli-Responsive Systems for Drug Delivery

被引：618

作者：

Cai, Wen ^{[1
]}

Wang, Junqing ^{[2
,3
]}

Chu, Chengchao ^{[2
,3
]}

Chen, Wei ^{[1
]}

Wu, Chunsheng ^{[1
]}

Liu, Gang ^{[2
,3
]}

机构：

[1] Xi An Jiao Tong Univ, Hlth Sci Ctr, Inst Med Engn, Dept Biophys,Sch Basic Med Sci, Xian 710061, Shaanxi, Peoples R China

[2] Xiamen Univ, State Key Lab Mol Vaccinol & Mol Diagnost, Sch Publ Hlth, Xiamen 361102, Peoples R China

[3] Xiamen Univ, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China

来源：

ADVANCED SCIENCE | 2019年 / 6卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

cancer therapy; drug delivery; metal-organic frameworks (MOFs); nanoparticles; stimuli responsive; NANOSCALE COORDINATION POLYMERS; ONE-POT SYNTHESIS; CONTROLLED-RELEASE; MAGNETIC-RESONANCE; MESOPOROUS SILICA; EXTERNAL-STIMULI; PH; NANOPARTICLES; THERAPY; ENCAPSULATION;

D O I：

10.1002/advs.201801526

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

With the rapid development of nanotechnology, stimuli-responsive nanomaterials have provided an alternative for designing controllable drug delivery systems due to their spatiotemporally controllable properties. As a new type of porous material, metal-organic frameworks (MOFs) have been widely used in biomedical applications, especially drug delivery systems, owing to their tunable pore size, high surface area and pore volume, and easy surface modification. Here, recent progress in MOF-based stimuli-responsive systems is presented, including pH-, magnetic-, ion-, temperature-, pressure-, light-, humidity-, redox-, and multiple stimuli-responsive systems for the delivery of anticancer drugs. The remaining challenges and suggestions for future directions for the rational design of MOF-based nanomedicines are also discussed.

引用

页数：20

共 96 条

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