Palladium-catalyzed aryl amination-heck cyclization cascade: A one-flask approach to 3-substituted Indoles

被引：139

作者：

Jensen, Thomas ^{[1
]}

Pedersen, Henrik ^{[2
]}

Bang-Andersen, Benny ^{[2
]}

Madsen, Robert ^{[1
]}

Jorgensen, Morten ^{[2
]}

机构：

[1] Tech Univ Denmark, Dept Chem, Ctr Sustainable & Green Chem, DK-2800 Lyngby, Denmark

[2] H Lundbeck & Co AS, DK-2500 Copenhagen, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 05期

关键词：

amination; Heck reaction; indoles; palladium; phosphane ligands;

D O I：

10.1002/anie.200703763

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Two for the price of one: A Pd/dppf-based catalyst provides access to the title compounds from 1,2-dihalogenated aromatic compounds and allylic amines in a single reaction flask. The initial aryl amination step occurs with excellent selectivity for the aryl iodide to ensure the formation of a single indole regioisomer, which can be functionalized in situ by N-arylation (see scheme). dba = dibenzylideneacetone, dppf = 1,1′-bis(diphenylphospanyl)ferrocene. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：888 / 890

页数：3

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