A new resveratrol hexamer from Upuna borneensis

被引：20

作者：

Ito, T

Tanaka, T

Ali, Z

Akao, Y

Nozawa, Y

Takahashi, Y

Sawa, R

Nakaya, K

Murata, J

Darnaedi, D

Iinuma, M

机构：

[1] Gifu Prefectural Inst Hlth & Environm Sci, Kakamigahara 5040838, Japan

[2] Gifu Int Inst Biotechnol, Kakamigahara 5040838, Japan

[3] Microbial Chem Res Ctr, Shinagawa Ku, Tokyo 1410021, Japan

[4] Univ Tokyo, Bot Gardens, Grad Sch Sci, Bunkyo Ku, Tokyo 1120001, Japan

[5] Indonesian Inst Sci, Res & Dev Ctr Biol, Bogor 16122, Indonesia

[6] Gifu Pharmaceut Univ, Gifu 5028585, Japan

来源：

HETEROCYCLES | 2004年 / 63卷 / 01期

关键词：

dipterocarpaceae; resveratrol oligomer; dibenzobicyclo[3.2.1]octadiene ring; structure elucidation; apoptosis;

D O I：

10.3987/COM-03-9917

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A new resveratrol hexamer, upunaphenol A, was isolated from an acetone soluble part of stem of Upuna borneensis (Dipterocarpaceae). The structure, which has twelve asymmetric carbon atoms on the partial structures of a dibenzobicyclo[3.2.1]octadiene ring and four dihydrobenzofuran rings, was determined by spectral analysis including ID and 2D NMR spectral experiments. Resveratrol and four known resveratrol oligomers, ampelopsin F, isoampelopsin F, vaticanols C and B, were also isolated. Upunaphenol A was found to suppress cell growth in HL60 cells through induction of apoptosis with IC50 at 9.2 muM.

引用

页码：129 / +

页数：9

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