Detection of eosinophils in hypertonic saline-induced sputum in patients with chronic nonproductive cough

被引：42

作者：

Fujimura, M

Songur, N

Kamio, Y

Matsuda, T

机构：

[1] Third Dept. of Int. Med. Kanazawa, University School of Medicine, Kanazawa 920

[2] Third Dept. of Internal Medicine, Kanazawa University, School of Medicine, Kanazawa 920

来源：

JOURNAL OF ASTHMA | 1997年 / 34卷 / 02期

关键词：

eosinophils; induced sputum; hypertonic saline; bronchial asthma; cough variant asthma; bronchodilator-resistant cough associated with atopy;

D O I：

10.3109/02770909709075656

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This study was conducted to examine (1) whether an appropriate sputum can be obtained by inducing with inhalation of hypertonic saline in patients with chronic nonproductive cough and (2) whether eosinophils can be detected in the induced sputum. Appropriate samples were obtained by the induction in 25 of 31 patients with bronchial asthma (BA), 12 of 17 patients with cough-variant asthma (CVA), 17 of 20 patients with bronchodilator-resistant cough associated with atopy (atopic cough, AC), and 23 of 25 healthy subjects. Eosinophils were detected in the successfully induced sputum in 100%, 66.6%, and 88.2% of the patients with BA, CVA, and AC, respectively. Detection of eosinophils in induced sputum may be the initial diagnostic procedure for nonproductive cough of allergic nature.

引用

页码：119 / 126

页数：8

共 25 条

[11] COUGH RECEPTOR SENSITIVITY AND BRONCHIAL RESPONSIVENESS IN PATIENTS WITH ONLY CHRONIC NONPRODUCTIVE COUGH - IN VIEW OF EFFECT OF BRONCHODILATOR THERAPY [J].