Gene therapy - The moving finger

被引:10
作者
High, KA [1 ]
机构
[1] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
关键词
D O I
10.1038/435577a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
DNA-cleaving enzymes trigger a repair process that can now be harnessed to correct mutations in the human genome in vitro. This represents another step towards gene-correction strategies for treating human disease.
引用
收藏
页码:577 / +
页数:2
相关论文
共 8 条
[1]   Enhancing gene targeting with designed zinc finger nucleases [J].
Bibikova, M ;
Beumer, K ;
Trautman, JK ;
Carroll, D .
SCIENCE, 2003, 300 (5620) :764-764
[2]   Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease [J].
Cavazzana-Calvo, M ;
Hacein-Bey, S ;
Basile, CD ;
Gross, F ;
Yvon, E ;
Nusbaum, P ;
Selz, F ;
Hue, C ;
Certain, S ;
Casanova, JL ;
Bousso, P ;
Le Deist, F ;
Fischer, A .
SCIENCE, 2000, 288 (5466) :669-672
[3]   A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency [J].
Hacein-Bey-Abina, S ;
von Kalle, C ;
Schmidt, M ;
Le Deist, F ;
Wulffraat, N ;
McIntyre, E ;
Radford, I ;
Villeval, JL ;
Fraser, CC ;
Cavazzana-Calvo, M ;
Fischer, A .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (03) :255-256
[4]   Hybrid restriction enzymes: Zinc finger fusions to Fok I cleavage domain [J].
Kim, YG ;
Cha, J ;
Chandrasegaran, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (03) :1156-1160
[5]   Towards therapeutic applications of engineered zinc finger proteins [J].
Klug, A .
FEBS LETTERS, 2005, 579 (04) :892-894
[6]   Chimeric nucleases stimulate gene targeting in human cells [J].
Porteus, MH ;
Baltimore, D .
SCIENCE, 2003, 300 (5620) :763-763
[7]   Expressing the human genome [J].
Tupler, R ;
Perini, G ;
Green, MR .
NATURE, 2001, 409 (6822) :832-833
[8]   Highly efficient endogenous human gene correction using designed zinc-finger nucleases [J].
Urnov, FD ;
Miller, JC ;
Lee, YL ;
Beausejour, CM ;
Rock, JM ;
Augustus, S ;
Jamieson, AC ;
Porteus, MH ;
Gregory, PD ;
Holmes, MC .
NATURE, 2005, 435 (7042) :646-651