Exploiting the Maitland-Japp reaction:: a synthesis of (±)-centrolobine

被引：50

作者：

Clarke, PA ^{[1
]}

Martin, WHC ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

TETRAHEDRON | 2005年 / 61卷 / 23期

基金：

英国工程与自然科学研究理事会;

关键词：

multi-component; tetrahydropyran Maitland-Japp; centrolobine;

D O I：

10.1016/j.tet.2005.04.011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Application of our one-pot, three-component variation of the Maitland-Japp reaction has led to the formation of a tetrahydropyran-4-one. which was converted in three steps to the antiparasitic and antibiotic natural product (+/-) centrolobine. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5433 / 5438

页数：6

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