Programming multiple protein patterns on a single DNA nanostructure

被引：60

作者：

Cohen, Justin D. ^{[1
]}

Sadowski, John P. ^{[1
]}

Dervan, Peter B. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 02期

关键词：

D O I：

10.1021/ja0772400

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pyrrole-imidazole polyamide conjugates recruit protein to uniquely addressable sites on a four tile DX array. Conjugates in combination lead to unique patterns with distinct spacing. Polyamide binding is sequence specific and requires no structural or chemical modification of the target DNA allowing the same DNA template to be used to create a variety of assemblies.

引用

页码：402 / +

页数：3

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