Issues in the analysis of oligonucleotide tiling microarrays for transcript mapping

被引：72

作者：

Royce, TE

Rozowsky, JS

Bertone, P

Samanta, M

Stolc, V

Weissman, S

Snyder, M

Gerstein, M ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

[2] Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT 06520 USA

[3] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[4] Systemix Inc, Cupertino, CA 95014 USA

[5] NASA, Ames Res Ctr, Genome Res Facil, Moffett Field, CA 94035 USA

[6] Yale Univ, Dept Genet, New Haven, CT 06520 USA

[7] Yale Univ, Dept Comp Sci, New Haven, CT 06520 USA

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 08期

关键词：

D O I：

10.1016/j.tig.2005.06.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Traditional microarrays use probes complementary to known genes to quantitate the differential gene expression between two or more conditions. Genomic tiling microarray experiments differ in that probes that span a genomic region at regular intervals are used to detect the presence or absence of transcription. This difference means the same sets of biases and the methods for addressing them are unlikely to be relevant to both types of experiment. We introduce the informatics challenges arising in the analysis of tiling microarray experiments as open problems to the scientific community and present initial approaches for the analysis of this nascent technology.

引用

页码：466 / 475

页数：10

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