Two Unusual Xanthones from the Bark of Garcinia xanthochymus

被引：19

作者：

Chen, Yu ^{[1
,2
,3
]}

Fan, Hua ^{[4
]}

Yang, Guang-Zhong ^{[1
,2
,4
]}

Jiang, Yan ^{[4
]}

Zhong, Fang-Fang ^{[4
]}

He, Hong-Wu ^{[1
,2
]}

机构：

[1] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[3] S Cent Univ Nationalities, Coll Chem & Mat Sci, Wuhan 430074, Peoples R China

[4] S Cent Univ Nationalities, Coll Pharm, Lab Nat Prod Chem, Wuhan 430074, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2011年 / 94卷 / 04期

基金：

中国国家自然科学基金;

关键词：

PRENYLATED XANTHONES; ROOT BARK; ANTIOXIDANT; FRUITS; SUBELLIPTICA;

D O I：

10.1002/hlca.201000287

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A new xanthone derivative, garcinexanthone F (1), which was found to possess an alpha,beta-unsaturated gamma-lactone moiety, and a new bisxanthone, bigarcinenone B (2), with a terpene bridge providing the xanthone-xanthone linkage, were isolated from the bark of Garcinia xanthochymus. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. The antioxidant assay in vitro showed that compounds 1 and 2 exhibited significant scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical with IC(50) values of 22.32 and 20.14 mu m, and against HO(center dot). radical with IC(50) values of 1.16 and 2.85 mu m, respectively.

引用

页码：662 / 668

页数：7

共 25 条

[1]

Bioactive benzophenones from Garcinia xanthochymus fruits [J].