Cytotoxic prenylated phenolic compounds from the twig bark of Garcinia xanthochymus

被引：51

作者：

Han, Quan-Bin

Qiao, Chun-Feng

Song, Jing-Zheng

Yang, Nian-Yun

Cao, Xin-Wei

Peng, Yong

Yang, Da-Jian

Chen, Shi-Lin

Xu, Hong-Xi ^{[1
]}

机构：

[1] Hong Kong Jockey Club Inst Chinese Med, Lab Chinese Med, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100083, Peoples R China

[4] Peking Union Med Coll, Beijing 100083, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 05期

关键词：

D O I：

10.1002/cbdv.200790083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.

引用

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页码：940 / 946

页数：7

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