Titanium-catalyzed intermolecular hydroamination of vinylarenes

被引：106

作者：

Kaspar, LT ^{[1
]}

Fingerhut, B ^{[1
]}

Ackermann, L ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 37期

关键词：

alkenes; catalysis; heterocycles; hydroamination; titanium;

D O I：

10.1002/anie.200501423

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The Lewis acid TiCl4 allows the intermolecular hydroamination of vinylarenes (see scheme). Some of the hydroamination products undergo rearrangements to give ortho-alkylated compounds. The catalyst tolerates a range of functional groups (R′ = CF3, Cl, CN, F, Br) and provides the products in good yields. This method was also applied to the synthesis of a tetrahydroisoquinoline derivative. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5972 / 5974

页数：3

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