Complexes of Cu(II) with 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-piperazine (prazosin): synthesis, properties, crystal structure

Two new copper(II)-prazosin (Prz) complex compounds, the binuclear green complex Cu(2)Prz(2)Cl(2)(CH3O)(2) (1) and the complex salt prazosinium tetrachlorocuprate(II) [HPrz](2)[CuCl4] (2), have been synthesized and characterized by chemical analysis, electronic spectra, IR and EPR spectroscopy, magnetochemical, thermogravimetric, calorimetric and X-ray diffraction methods. Each of the Cu(II) centers in the binuclear complex (1) is four-coordinated by two bridging CH, groups, one Prz molecule, monodentately bound through the NH, group and one terminal Cl atom. The crystal structure of the complex salt (2) was solved by the single crystal X-ray diffraction method. The structure consists of CuCl42 anions and protonated prazosin [HPrz] (+) cations. A network of -NH3+ . . .O=C hydrogen bonds links the [HPrz](+) cations into layers, parallel to the ac plane, whereas other H-bonds of the type -NH3+. . . Cl-Cu exist between the CuCl42- moiety and the protonated amino group of the ligand. (C) 2001 Elsevier Science B.V. All rights reserved.