New isocysteine building blocks and chemoselective peptide ligation

被引：22

作者：

Dose, C ^{[1
]}

Seitz, O ^{[1
]}

机构：

[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 01期

关键词：

D O I：

10.1039/b309235f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Boc-, Fmoc- and Cbz-protected isocysteine building blocks were prepared by a concise three-step procedure starting from thiomalic acid. The use of Boc/Trt-protected isocysteine provided convenient access to isocysteinyl peptides that allow the chemoselective ligation of unprotected peptide fragments in water. The pH-dependency of the isocysteine-mediated ligation was compared with that of cysteine-mediated native chemical ligation.

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页码：59 / 65

页数：7

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