Histamine deficiency induces tissue-specific down-regulation of histamine H2 receptor expression in histidine decarboxylase knockout mice

被引:26
作者
Fitzsimons, CP
Lazar-Molnar, E
Tomoskozi, Z
Buzás, E
Rivera, ES
Falus, A
机构
[1] Semmelweis Univ, Sch Med, Dept Genet Cell & Immunobiol, H-1085 Budapest, Hungary
[2] Univ Buenos Aires, Sch Biochem & Pharm, Radioisotopes Lab, Buenos Aires, DF, Argentina
[3] Natl Acad Sci, Mol Immunol Res Grp, Budapest, Hungary
来源
FEBS LETTERS | 2001年 / 508卷 / 02期
关键词
histamine receptor; L-histidine decarboxylase; knockout mouse; G protein-coupled receptor; tissue-specific expression; histamine;
D O I
10.1016/S0014-5793(01)03070-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Histidine decarboxylase (HDC) is the single enzyme responsible for histamine synthesis. HDC-deficient mice (HDC-/-) have no histamine in their tissues when kept on a histamine-free diet. Therefore, the HDC-/- mice provide a suitable model to investigate the involvement of histamine in the regulation of histamine receptor expression. Gene expression of H1 and H2 histamine receptors was studied in several organs of HDC-/- mice and compared to standard (HDC+/+) mice. In many tissues, prolonged absence of histamine induced downregulation of the H2 receptor subtype. The expression of the HI receptor was less sensitive to histamine deficiency. Exogenous histamine present in the diet abolished the differences observed in H2 receptor expression. These results suggest that the expression of mouse H2 receptor is under the control of histamine in a tissue-specific manner. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:245 / 248
页数:4
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