Human fear-related motor neurocircuitry

被引：67

作者：

Butler, T. ^{[1
]}

Pan, H. ^{[1
]}

Tuescher, O. ^{[1
]}

Engelien, A. ^{[2
,3
]}

Goldstein, M. ^{[1
]}

Epstein, J. ^{[1
]}

Weisholtz, D. ^{[1
]}

Root, J. C. ^{[1
]}

Protopopescu, X. ^{[1
]}

Cunningham-Bussel, A. C. ^{[1
]}

Chang, L. ^{[1
]}

Xie, X. -H. ^{[1
]}

Chen, Q. ^{[1
]}

Phelps, E. A. ^{[4
]}

Ledoux, J. E. ^{[5
]}

Stern, E. ^{[1
]}

Silbersweig, D. A. ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, New York, NY 10021 USA

[2] Univ Munster, Dept Psychiat, Munster, Germany

[3] Univ Munster, Interdisciplinary Ctr Clin Res, Munster, Germany

[4] NYU, Dept Psychol, New York, NY 10003 USA

[5] NYU, Ctr Neural Sci, New York, NY 10003 USA

来源：

NEUROSCIENCE | 2007年 / 150卷 / 01期

关键词：

fMRI; anxiety; freezing; basal ganglia; motor cortex; amygdala;

D O I：

10.1016/j.neuroscience.2007.09.048

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using functional magnetic resonance imaging and an experimental paradigm of instructed fear, we observed a striking pattern of decreased activity in primary motor cortex with increased activity in dorsal basal ganglia during anticipation of aversive electrodermal stimulation in 42 healthy participants. We interpret this pattern of activity in motor neurocircuitry in response to cognitively-induced fear in relation to evolutionarily-conserved responses to threat that may be relevant to understanding normal and pathological fear in humans. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：1 / 7

页数：7

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