Heteroaryl substituted ansa-titanocene anti-cancer drugs derived from fulvenes and titanium dichloride

被引：74

作者：

Rehmann, FJK

Cuffe, LP

Mendoza, O

Rai, DK

Sweeney, N

Strohfeldt, K

Gallagher, WM

Tacke, M

机构：

[1] Univ Coll Dublin, Dept Chem, CSCB, Dublin 4, Ireland

[2] Univ Coll Dublin, Dept Pharmacol, Dublin 4, Ireland

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2005年 / 19卷 / 03期

关键词：

anti-cancer drug; cis-platinum; titanocene; fulvene; LLC-PK; DFT calculations;

D O I：

10.1002/aoc.864

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Starting from 2-furylfulvene (la), 2-thiophenylfulvene (1b), and 1-methyl-2-pyrrolylfulvene (1c), [1,2di(cyclopentadienyl)-1,2-di-(2-furyl)ethanediyl] titanium dichloride (2a), [1,2-di(cyclopentadienyl)1,2-di-(2-thiophenyl)ethanediyl] titanium dichloride (2b), and [1,2-di(cyclopentadienyl)-1,2-bis-(1methyl-2-pyrrolyl)ethanediyl] titanium dichloride (2c) were synthesized. When titanocenes (2a-c) were tested against pig kidney carcinoma cells (LLC-PK), inhibitory concentrations (50%) of 4.5 x 10(-4) M, 2.9 x 10(-4) M and 2.0 x 10(-4) M respectively were observed. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：293 / 300

页数：8

共 25 条

[1] Functionalized cyclopentadienyl titanium organometallic compounds as new antitumor drugs [J].