A Two-Component Small Molecule System for Activity-Based Detection and Signal Amplification: Application to the Visual Detection of Threshold Levels of Pd(II)

被引：111

作者：

Baker, Matthew S. ^{[1
]}

Phillips, Scott T. ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 14期

关键词：

PALLADIUM; CATALYSIS; CHEMODOSIMETER; FLUORIDE; SENSOR;

D O I：

10.1021/ja108347d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.

引用

页码：5170 / 5173

页数：4

共 28 条

[1] Self-immolative dendrimers: A distinctive approach to molecular amplification [J].

Avital-Shmilovici, Michal ;

Shabat, Doron .

SOFT MATTER, 2010, 6 (06) :1073-1080

[2] PCR'S next frontier [J].

Blow, Nathan .

NATURE METHODS, 2007, 4 (10) :869-+

[3] Analysis of the reactions used for the preparation of drug candidate molecules [J].

Carey, John S. ;

Laffan, David ;

Thomson, Colin ;

Williams, Mike T. .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2006, 4 (12) :2337-2347

[4] Modern reaction-based indicator systems [J].

Cho, Dong-Gyu ;

Sessler, Jonathan L. .

CHEMICAL SOCIETY REVIEWS, 2009, 38 (06) :1647-1662

[5] Highly sensitive and selective Pd2+ sensor of naphthalimide derivative based on complexation with alkynes and thio-heterocycle [J].

Duan, Liping ;

Xu, Yufang ;

Qian, Xuhong .

CHEMICAL COMMUNICATIONS, 2008, (47) :6339-6341

[6] Studies of a fluorogenic probe for palladium and platinum leading to a palladium-specific detection method [J].

Garner, Amanda L. ;

Koide, Kazunori .

CHEMICAL COMMUNICATIONS, 2009, (01) :86-88

[7] Enhancement of a Catalysis-Based Fluorometric Detection Method for Palladium through Rational Fine-Tuning of the Palladium Species [J].

Garner, Amanda L. ;

Song, Fengling ;

Koide, Kazunori .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (14) :5163-5171

[8] Oxidation State-Specific Fluorescent Method for Palladium(II) and Platinum(IV) Based on the Catalyzed Aromatic Claisen Rearrangement [J].

Garner, Amanda L. ;

Koide, Kazunori .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (49) :16472-+

[9] Drivers of biodiagnostic development [J].

Giljohann, David A. ;

Mirkin, Chad A. .

NATURE, 2009, 462 (7272) :461-464

[10]

GOSLING JP, 1990, CLIN CHEM, V36, P1408

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