2-Cyanopyridazin-3(2H)-ones:: effective and chemoselective electrophilic cyanating agents

被引：48

作者：

Kim, JJ

Kweon, DH

Cho, SD

Kim, HK

Jung, EY

Lee, SG

Falck, JR

Yoon, YJ ^{[1
]}

机构：

[1] Gyeongsang Natl Univ, Dept Chem & Environm Biotechnol, Natl Core Res Ctr, Chinju 660701, South Korea

[2] Changwon Natl Univ, Dept Chem, Chang Won 641773, South Korea

[3] Changwon Natl Univ, Res Inst Basic Sci, Chang Won 641773, South Korea

[4] Gyeongsang Natl Univ, Dept Chem, Chinju 660701, South Korea

[5] Gyeongsang Natl Univ, Res Inst Life Sci, Chinju 660701, South Korea

[6] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

来源：

TETRAHEDRON | 2005年 / 61卷 / 24期

关键词：

N-; S or C-cyanation; electrophilic cyanating agent; 2-Cyanopyridazin-3(2H)-ones;

D O I：

10.1016/j.tet.2005.03.138

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Cyanopyridazin-3(2H)-ones are novel, effective, selective and electrophilic cyanating agents. A variety of amino, thiol and carbon nucleophiles are chemoselectively N-, S- or C-cyanated in excellent yield using 2-cyanopyridanzin-3(2H)-ones in water or tetrahydrofuran. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5889 / 5894

页数：6

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