Spontaneous self-assembly of water-soluble nucleotide-calixarene conjugates in small micelles coalescing to microspheres

被引：34

作者：

Consoli, Grazia M. L. ^{[1
]}

Granata, Giuseppe ^{[1
]}

Lo Nigro, Raffaella ^{[2
]}

Malandrino, Graziella ^{[3
]}

Geraci, Corrada ^{[1
]}

机构：

[1] CNR, Ist Chim Biomol, I-95028 Valverde, CT, Italy

[2] CNR, Ist Microelettron & Microsistemi, I-95125 Catania, Italy

[3] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

来源：

LANGMUIR | 2008年 / 24卷 / 12期

关键词：

D O I：

10.1021/la800286p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Spontaneous self-assembly of calix[4]arenes bearing four 2'-deoxythymidine or 2'-deoxyadenosine nucleotide pendants is investigated using H-1 NMR, exchange NMR, and diffusion ordered NMR spectroscopies and dynamic light scattering. In aqueous medium, the nucleotide-calixarene conjugates, by noncovalent interactions involving both nucleobases and calixarene skeleton, form dimers which self-organize in micelles by increasing the concentration. Microscopic images (scanning electron microscopy and transmission electron microscopy) show that the nucleobase affects the aggregate morphology in the solid state.

引用

页码：6194 / 6200

页数：7

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