Improved procedure for the room temperature asymmetric phase-transfer mediated epoxidation of α,β-unsaturated ketones

被引:71
作者
Lygo, B [1 ]
To, DCM [1 ]
机构
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
关键词
D O I
10.1016/S0040-4039(00)02208-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Studies into the factors affecting the rate of reaction in the enantioselective epoxidation of alpha,beta -unsaturated ketones utilising Cinchona alkaloid-derived quaternary ammonium phase-transfer catalysts are reported. This has led to the identification of improved conditions for the room temperature epoxidation process, which require only I mol% catalyst and lead to isolation of the epoxide products in high enantiomeric excess. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码:1343 / 1346
页数:4
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