RNAi screening for therapeutic targets in human malignancies

被引：19

作者：

Micklem, David R. ^{[1
]}

Lorens, James B. ^{[1
]}

机构：

[1] Univ Bergen, Dept Biomed, N-5009 Bergen, Norway

来源：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2007年 / 8卷 / 06期

关键词：

RNA interference; genetic screen; cancer; therapeutic target;

D O I：

10.2174/138920107783018426

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The advent of RNA interference (RNAi) based library screening approaches has sparked a surge in loss-of-function genetic screens. Several recent screens have aimed to identify novel regulators of cancer-related phenotypes. These employ various tumor cell types to model malignant cell functions and use different RNAi effector library approaches to reveal a cache of novel tumor regulators. This review surveys recent RNAi screens conducted in transformed human cells.

引用

收藏

页码：337 / 343

页数：7

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