Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease

被引：27

作者：

Winkler, Susan

Koenig, Inke R.

Lohmann-Hedrich, Katja

Vieregge, Peter

Kostic, Vladimir

Klein, Christine

机构：

[1] Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany

[2] Univ Lubeck, Dept Human Genet, Lubeck, Germany

[3] Univ Lubeck, Inst Med Biometry & Stat, Lubeck, Germany

[4] Hosp Lippe Lemgo, Dept Neurol, Lemgo, Germany

[5] Univ Belgrade, Dept Neurol, Belgrade, Serbia

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2007年 / 15卷 / 11期

关键词：

Parkinson's disease; MAPT haplotypes; ethnicity;

D O I：

10.1038/sj.ejhg.5201901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An association of the H1 haplotype and subhaplotypes in the microtubule-associated protein Tau (MAPT) gene with Parkinson's disease (PD) has been reported. To further evaluate their role in PD, we genotyped a sample set of 765 cases and controls consisting of two large European subgroups of German (n 418) and Serbian (n = 347) origin for the MAPT haplotypes H1 and H2. The H1/H1 carriers were tested for three additional MAPT polymorphisms. In the Serbian sample, there was significant evidence (P = 0.0108) of an association of the H1/H1 genotype and PD. Surprisingly, in the German sample, we did not find significant differences in genotype or haplotype frequencies between patients and controls. These results suggest that the role of H1 haplotypes in the etiology of PD may be ethnically dependent.

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页码：1163 / 1168

页数：6

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