Association of the Tau haplotype with Parkinson's disease in the Greek population

被引：22

作者：

Fidani, Liana ^{[1
]}

Kalinderi, Kallirhoe

Bostantjopoulou, Sevasti

Clarimon, Jordi

Goulas, Antonis

Katsarou, Zoe

Hardy, John

Kotsis, Alexandros

机构：

[1] Aristotle Univ Thessaloniki, Sch Med, Dept Gen Biol, GR-54124 Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, G Papanikolau Hosp, Dept Neurol 3, GR-54006 Thessaloniki, Greece

[3] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[4] Aristotle Univ Thessaloniki, Sch Med, Dept Pharmacol, GR-54006 Thessaloniki, Greece

[5] Reta Lila Weston Inst Neurol, London, England

来源：

MOVEMENT DISORDERS | 2006年 / 21卷 / 07期

基金：

英国医学研究理事会;

关键词：

Tau; polymorphisms; haplotypes; Parkinson's disease;

D O I：

10.1002/mds.20864

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We compared the distribution of the Tau HI haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to,detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% Cl: 1.03-2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation. (C) 2006 Movement Disorder Society.

引用

页码：1036 / 1039

页数：4

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