2-azetidinone cholesterol absorption inhibitors: Increased potency by substitution of the C-4 phenyl ring

被引：24

作者：

Vaccaro, WD ^{[1
]}

Sher, R ^{[1
]}

Davis, HR ^{[1
]}

机构：

[1] Schering Plough Corp, Inst Res, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 09期

关键词：

D O I：

10.1016/S0968-0896(98)00073-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SAR studies directed towards the optimization of 2-azetidinone cholesterol absorption inhibitors led to the discovery of 11a, the most potent cholesterol absorption inhibitor yet identified. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1429 / 1437

页数：9

共 13 条

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