Human genetic susceptibility to infectious disease

被引：345

作者：

Chapman, Stephen J. ^{[1
]}

Hill, Adrian V. S. ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; CHRONIC HEPATITIS-C; CHRONIC MUCOCUTANEOUS CANDIDIASIS; ANHIDROTIC ECTODERMAL DYSPLASIA; PYOGENIC BACTERIAL-INFECTIONS; HERPES-SIMPLEX ENCEPHALITIS; HYPER-IGE SYNDROME; HIV-1; INFECTION; MENINGOCOCCAL DISEASE; IMMUNE-DEFICIENCY;

D O I：

10.1038/nrg3114

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Recent genome-wide studies have reported novel associations between common polymorphisms and susceptibility to many major infectious diseases in humans. In parallel, an increasing number of rare mutations underlying susceptibility to specific phenotypes of infectious disease have been described. Together, these developments have highlighted a key role for host genetic variation in determining the susceptibility to infectious disease. They have also provided insights into the genetic architecture of infectious disease susceptibility and identified immune molecules and pathways that are directly relevant to the human host defence.

引用

页码：175 / 188

页数：14

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