Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines

被引：23

作者：

Tyvorskii, VI

Bobrov, DN

Kulinkovich, OG

Tehrani, KA

De Kimpe, N

机构：

[1] Belarusian State Univ, Dept Organ Chem, Minsk 220050, BELARUS

[2] Univ Ghent, Fac Agr & Appl Biol Sci, Dept Organ Chem, B-9000 Ghent, Belgium

来源：

TETRAHEDRON | 2001年 / 57卷 / 10期

关键词：

4H-pyran-4-ones; 4-aminopyridines; 1H-pyrazolo[4,3-c]pyridines; Smiles rearrangement;

D O I：

10.1016/S0040-4020(01)00024-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H-pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2051 / 2055

页数：5

共 17 条

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