The studies of anti-inflammatory and analgesic activities and pharmacokinetics of Oxytropis falcate Bunge extraction after transdermal administration in rats

被引：17

作者：

Chen, Zhi-peng ^{[1
]}

Qu, Min-ming ^{[1
]}

Chen, Hong-xuan ^{[2
]}

Liu, Dan ^{[3
]}

Xiao, Yan-yu ^{[3
]}

Chen, Jun ^{[1
]}

Lu, Tu-lin ^{[1
]}

Cai, Bao-chang ^{[1
]}

机构：

[1] Nanjing Univ Tradit Chinese Med, Dept Pharm, Nanjing 210046, Peoples R China

[2] Henan Univ, Dept Pharm, Kaifeng 475001, Peoples R China

[3] China Pharmaceut Univ, Nanjing 210009, Peoples R China

来源：

FITOTERAPIA | 2011年 / 82卷 / 03期

关键词：

Oxytropis falcate Bunge; Total flavonoids; Anti-inflammatory; Analgesic activity; Pharmacokinetics;

D O I：

10.1016/j.fitote.2010.11.026

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The aim of this study was to evaluate the activities of anti-inflammatory and analgesic of the total flavonoids extraction from Oxytropis falcate Bunge (FR)) after transdermal administration. The pharmacokinetics and absolute bioavailability of FE) in rat, furthermore, was studied. Firstly, the anti-inflammatory and analgesic effects of the FE were studied by xylene-induced ear edema, adjuvant-induced joint inflammation law in rats, acetic acid-induced writhing and hot-plate tests in mice. Secondly, we developed a sensitive and specific HPLC method to analyze 2', 4'-dihydroxychalcone (TFC, the mainly ingredient of FEO) in rat plasma to study the pharmacokinetic of TEC. The results showed FE has anti-inflammatory and analgesic property in a dose-dependent manner, and that the high dose group (90.6 mg/kg) of FEO appeared more significantly effective than the positive drug. From the pharmacokinetic studies of TFC in rats, we got the main pharmacokinetic parameters of TFC, providing a basis for the future studies in clinic. (c) 2010 Elsevier B.V. All rights reserved.

引用

页码：426 / 433

页数：8

共 22 条

[1]

Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis [J].