Autologous Mesenchymal Stem Cells Foster Revascularization of Ischemic Limbs in Systemic Sclerosis A Case Report

被引：93

作者：

Guiducci, Serena ^{[1
]}

Porta, Francesco ^{[1
]}

Saccardi, Riccardo ^{[1
]}

Guidi, Stefano ^{[1
]}

Ibba-Manneschi, Lidia ^{[1
]}

Manetti, Mirko ^{[1
]}

Mazzanti, Benedetta ^{[1
]}

Dal Pozzo, Simone ^{[1
]}

Milia, Anna Franca ^{[1
]}

Bellando-Randone, Silvia ^{[1
]}

Miniati, Irene ^{[1
]}

Fiori, Ginevra ^{[1
]}

Fontana, Rossana ^{[1
]}

Amanzi, Laura ^{[1
]}

Braschi, Francesca ^{[1
]}

Bosi, Alberto ^{[1
]}

Matucci-Cerinic, Marco ^{[1
]}

机构：

[1] Univ Florence, Div Rheumatol, Azienda Osped Univ Careggi, Dept Biomed,Denothe Ctr, I-50139 Florence, Italy

来源：

ANNALS OF INTERNAL MEDICINE | 2010年 / 153卷 / 10期

关键词：

ENDOTHELIAL-CELLS; TRANSPLANTATION; ANGIOGENESIS;

D O I：

10.7326/0003-4819-153-10-201011160-00007

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background: Mesenchymal stem cells can differentiate into endothelial cells and participate in angiogenesis in adults. In experimental models of acute myocardial infarction, mesenchymal stem cells led to the recovery of cardiac function through the formation of a new vascular network. Objective: To describe treatment with intravenous infusions of expanded autologous mesenchymal stem cells in 1 patient with critical limb ischemia due to systemic sclerosis. Design: Case report. Setting: The rheumatology unit at the University of Florence, Florence, Italy. Patient: A woman, aged 34 years, with systemic sclerosis who developed acute gangrene of the upper and lower limbs. Intervention: 3 intravenous pulses of expanded autologous mesenchymal stem cells. Measurements: Angiography, skin histopathology, and immunohistochemistry. Results: Areas of necrotic skin were reduced after the first mesenchymal stem-cell infusion. After the third infusion, angiography showed revascularization of the patient's extremities. Skin section analysis revealed cell clusters with tubelike structures, and angiogenic factors were strongly expressed. Limitation: Causality cannot be established by a single case. Conclusion: In patients with systemic sclerosis who have severe peripheral ischemia, intravenous infusion of expanded autologous mesenchymal stem cells may foster the recovery of the vascular network, restore blood flow, and reduce skin necrosis.

引用

页码：650 / 654

页数：5

共 15 条

[1]

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