Synthesis of 3-substituted indazoles and benzoisoxazoles via Pd-catalyzed cyclization reactions: application to the synthesis of nigellicine

被引：88

作者：

Inamoto, Kiyofumi ^{[1
]}

Katsuno, Mika

Yoshino, Takashi

Arai, Yukari

Hiroya, Kou

Sakamoto, Takao

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

[2] Tohoku Univ, 21st Century COE Program, Comprehens Res & Educ Ctr Planning Drug Dev & Cli, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON | 2007年 / 63卷 / 12期

关键词：

palladium; animation; hydrazone; indazole; benzoisoxazole; nigellicine;

D O I：

10.1016/j.tet.2007.01.010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of 3-substituted indazoles and benzoisoxazoles were efficiently accomplished with the aid of Pd-catalyzed intramolecular carbon-nitrogen and carbon-oxygen bond formations. The catalyst system described herein allows the cyclization to proceed under very mild conditions and thus could be applied to a wide range of substrates with acid- or base-sensitive functional groups. A total synthesis for the indazole ring-containing natural product nigellicine is also described. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2695 / 2711

页数：17

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